COLLABORATIVE OR PRINCIPLED NEGOTIATION Assignment - 1

COLLABORATIVE OR PRINCIPLED NEGOTIATION - Assignment Example It will also be very important not to ignore the fact that principled negotiation is thorough in terms of the factors that are considered and the presentation of the various requirements of the software stakeholders. This is a technique that has proved to be effective for a person who intends to separate the problem from the stakeholders. For example, clients might not have the same computing background as the suppliers or developers. This implies that there should be a way through which the requirements can take into consideration the difference in the nature of the differences of the stakeholders if in any case the project is to become a success. This is a method that can also enable engineering of requirements to be based on the interests of the negotiators rather than their positions. Through focusing on the interests, a software developer might be able to determine the common ground for all the stakeholders. This is basically because he nature of the software that is developed will need to be in accordance to the requirements of the suppliers and the end users. This negotiation approach also allows for the invention of mutual gain. One thing about computers system is that they usually evolve with time. For instance, in this case it was discovered that the money that was availed by the government would not be sufficient for the required hardware for the necessary spreading of implementation functionality. Therefore, the negotiation process led to the division of the whole project into phases with the first phase being the most important one which was food control. The division into phases was a result of thorough study of the interests of the stakeholder and looking of the most appropriate way through which all the stakeholders would be satisfied even with the limited resources. The fact that people rarely change their positions,

Inventory System Summary Essay Example | Topics and Well Written Essays - 750 words

Inventory System Summary - Essay Example This paper aims to discuss periodic inventory systems and its advantages and disadvantages. A periodic inventory system is a system where data is entered after a specific duration of time (Wensing, 2011). It is here where the term periodic is derived. Data is updated after a specific period, in the inventory systems, unlike in perpetual inventory systems where data is entered as sales are made. Information for this system is not kept up to date. While information for the inventory is noted, total and permanent storage of this data is only entered once a year. Under this inventory system, the amount recorded, in the account for inventory, is not updated after sales of goods or services are made (Wensing, 2011). The inventory account is updated once or adjusted one time usually per annum. During the current year, the inventory will only show the previous year’s end cost of inventory. Under this system, service and merchandise purchase is made, in either one or more than one purchase accounts. There is closure of purchase accounts and adjustment of the inventory account to equal the services and merchandise that is, in hand at that time, at the end of the year. This system has no cost of goods or services sold account for updating after a sale (Wensing, 2011). Periodic inventories utilize simple modes of calculation, in order to maintain an account for inventory, in the general ledger (Wensing, 2011). Materials and services purchased are entered, in a purchase account. A single entry is made moving to COGS sold material, at the end of a period of accounting. A periodic inventory only requires the total purchases and total sales entered on a monthly basis. There is no need for inventory count accounting records since the maintenance of the inventory is done through the entry of journals, in the general ledger (Wensing, 2011). The only records that are kept physically are derived from the

Serious dramatic deficiency Essay Example for Free

Serious dramatic deficiency Essay It is not only in period pieces, however, that the rejection of our countrys history and tradition robs actors performances of authenticity. In postwar Japans cultural climate, it is exceedingly difficult for actors in any type of role to convincingly express complex, deep or intense emotion — in fact, any dramatic emotion at all. To appear real, this sort of emotional expression demands exactly the right modulation and combination of subtle elements, including not only choice of words and facial expression, but also posture, gesture, tone of voice, direction of gaze, and distance from other actors. And the right modulation and combination differs from culture to culture. Every culture has its own framework of expressive conventions from which actors must draw in order to express emotion that will strike their audience as authentic. As long as Japanese actors refuse to work within the framework of emotional expression stipulated by Japanese culture, they cannot express dramatic emotion in a convincing manner. The famed Meiji-era novelist Natsume Soseki once taught his students that the true Japanese translation for I love you is Tsuki ga tottemo aoi na (The moon is so blue tonight); what he meant was that to express within the Japanese cultural framework the same emotion expressed in English by I love you, one must choose words like The moon is so blue tonight. Since every culture evolves naturally over time, the cultural framework for emotional expression is by no means immutable. But in post-war Japan the process of change has been unnatural and rushed. Regarding their traditional modes of expression as archaic and feudalistic, and eager to Westernize, the Japanese have attempted to adopt the Western (more specifically, the American) expressive framework wholesale. Yet given that they continue to use the Japanese language as their vehicle for verbal expression, any attempt to affect a de-Japanized manner at this level is half-baked. Today, one might say, a Japanese person is unable to convincingly express passion for another either by the English I love you or by the Japanese The moon is so blue tonight. This may be why, since the 1980s, young people in Japan have increasingly disdained the expression of serious or dramatic emotion as kusai, or corny, and prized the appearance of emotional detachment as kakko-ii, or cool. In terms of dramatic expression, then, the Japanese film labors under a heavy burden. If it portrays emotion within the traditional Japanese framework, it may achieve authenticity, but the effect is antiquated. If it portrays emotion within the Western framework, it comes across as meretricious and unconvincing. Films that try to blend the two modes often end up antiquated and unconvincing. Yet in animation, which lacks visual realism and features de-Japanized characters to begin with, the expression of emotion paradoxically takes on a more convincing sense of reality. This may explain why most of the serious and ambitious film efforts have used the vehicle of anime. Given the serious dramatic deficiency, Japanese live-action films can no longer tackle any serious or profound subject matter. In the context of contemporary Japanese film, then, anime often conveys a greater sense of reality than live-action films. The thin, insubstantial reality of animated film, that is to say, is more alive — literally, more animated — than the flesh-and-blood reality. And if anime is perceived as more real (i. e. , closer to physical reality) than live-action, this means that, increasingly, anime embodies the Japanese consciousness of reality. The Japanese conception of reality is undergoing a process of animation. The rise of anime as well as manga is a cultural by-product of modern Japans tendency to promote modernization and Westernization while rejecting its history and traditions. A medium that fuses elements of East and West, and lacks a clear national identity, could be considered international in a certain sense, and this is doubtless a major reason why anime has so many fans overseas. But the current state of affairs, in which anime represents the mainstream of Japanese cinema, is by no means desirable, inasmuch as it signifies an ever-widening gap between physical reality and peoples conception of it.

The Blood Clotting Cascade Biology Essay

The Blood Clotting Cascade Biology Essay von Willebrand Factor is a large multimeric clotting protein which plays a significant role in the process of blood coagulation. It is mainly secreted by the vascular endothelial cells and also by megakaryocytes in the bone marrow. The vWF performs two important functions in the process of blood coagulation, and thats why it is very important. First, it is responsible in bringing together the elements to form the primary hemostatic plug. It serves as an anchor for platelets at the site of injury in the blood vessel. Second, it acts as a protective chaperone for Factor VIII, to avoid lysis by proteolytic agents in the blood. The Factor VIII also released by vWF at the site of injury, whereby it brings about the completion of the Intrinsic Pathway of blood coagulation, and seals the site of injury with Fibrin. von Willebrand Disease (vWD) is the most common inherited bleeding disorder in human beings the world over. Although, mutations in the vWF gene are responsible for the type of vWD in a patient, the transmission of vWD to the next generation is not solely linked to the vWF gene, but involves linkages with other genes such as the ABO blood type genes. The gene that encodes von Willebrand Factor is present on the short chromatid of chromosome 12, and is 178kb long with 52 exons or coding sites. Most of the exons are small, some as small as 41 base pairs (Schneppenheim, 2011). Exon 28, which has 1379 base pairs, is the largest. Mutations in the genes encoding vWF are primarily responsible for most vWD cases. Mutations can cause qualitative or quantitative deficiencies of vWF. Mutations in the vWF gene and the vWD that is attributed to the mutations are shown in Figure 1. C:UsersTj WorkDropboxTjBlood SensorThesisvWF Domains rot.jpg Figure : Upper panel: vWF Exons coding for the domains; Lower panel: Locations of mutations and their corrseponding vWD types The multimeric von Willebrand Factor contains identical subunits of 250kDa each. These subunits dimerize (into 500 kilo Daltons subunits) and then multimerize into clusters greater than 10 mega Daltons in weight (Sadler JE, 2006). The vWF performs two functions serve as an anchor for binding platelets to the site of injury and bind to and stabilize Factor VIII from degradation by proteases in the blood and presenting it only at the site of injury. A vWF monomer has a repeated domain structure S D1 D2 D D3 A1 A2 A3 D4 B1 B2 B3 C1 C2 CK (Figure 1). The monomer is 2813 amino acids long. At the N-terminal is the 22 amino acid long signal peptide. Domains D and D3 are specific to Factor VIII binding. Platelets bind to vWF at its A1domain with their Glycoprotein (GP)-1b surface receptors. The A3 domain is specific to collagen, predominantly type III (J. Siekmann, 1998). Thus, domains A1 and A3 are necessary and must be fully functional to form the primary hemostatic plug in the process of coagulation. Figure 2: Domains of vWF protein, (U.S. Department of Health and Human Services, 2007) Overview of the clotting cascade A brief overview of the blood clotting cascade is necessary to understand the function of vWF in the process of clotting. The process of blood coagulation involves platelets and clotting proteins. At the site of injury in a blood vessel, the subendothelial collagen (types I and III) in the extracellular matrix of the blood vessel is exposed to blood. vWF that is present in the blood binds to the exposed collagen with its A3 domain. The flow of blood causes the multimers of the anchored vWF to unfold and expose the sites of platelet binding on the A1 domain (Figure 2). The platelets bind to this domain with their Gp-Ib receptor proteins present on the platelet cell surface. The binding of platelets to vWF activates them and a chemical messenger Thromboxane A2 is released by the platelets. Thromboxane A2 at the site of injury attracts more platelets in the blood, and aids in platelet aggregation. Platelets flowing in the blood stream bind to the activated platelets with a surface prot ein Gp IIb/IIIa. Fibrinogen (Factor I) is present in between the GP-IIb/IIIa receptors of two platelets. Thus, a primary hemostatic plug, though weak in strength, is formed. Figure 3: Sequence of events of blood coagulation due to vWF (U.S. Department of Health and Human Services, 2007) The unfolding of the multimers of vWF also releases Factor VIII at the site of injury. In the Intrinsic pathway of coagulation, Factor VIII is essential in catalyzing the conversion of Factor IX to Factor X, and eventually, prothrombin is catalyzed to from thrombin. Thrombin catalyzes the conversion of Fibrinogen (Factor I) into Fibrin. The fibrin forms a thick proteinaceous mesh, which seals the loss of blood from the blood vessel, this completing the process of hemostasis. Tissue repair and wound healing ensues. von Willebrand Disease von Willebrand Disease (vWD) is a deficiency of von Willebrand Factor. Based on the quantitative and qualitative deficiency, it is classified into subtypes. Combinations of assays are done to detect vWF levels in human plasma. Results of these tests report vWF levels in International Units per deciliter (IU/dL). The plasma concentration of vWF in healthy individuals is reported to be at around 10Â µg/mL (Mannucci, 1998), and the corresponding IU measurement is 100 IU/dL. The classification of the vWD types is based on the criteria developed by the vWF Subcommittee of the International Society of Thrombosis and Haemostasis at Carrboro, North Carolina, USA in 1994. Annual meetings are held by ISTH to review diagnosis and management guidelines for vWD by experts all over the world. The standard guidelines for the diagnosis and treatment of vWD in the USA is based on the vWF Report by the National Heart, Lung and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services, which was released in 2007 by the expert panel on vWF, chaired by Dr. William L. Nichols, Jr., M.D. The ISTH holds annual meetings all over the world to discuss updates on vWD. The first vWD classification by the ISTH in 1994 was based on information about mutations on the vWF gene. However, because it was appropriate to only a small population of the human race, it was overruled in 2006 and was replaced by the new method based on response to treatment with DDAVP or other blood based therapeutics. vWD is classified based on qualitative and quantitative deficiencies. Partial quantitative deficiency is type 1 vWD and total quantitative deficiency is type 3. Qualitative deficiency is type 2, and is subdivided into types 2A, 2B, 2M and 2N based on the functions of the vWF which are affected. Quantitative deficiencies of vWF are discussed first types 1 and 3 vWD. The main laboratory tests to analyze vWF in patient samples are vWF:Antigen activity (vWF:Ag), Factor VIII: Coagulation activity (FVIII:C) and vWF: Ristocetin Cofactor activity (vWF:RCo). Type 1 vWD A patient with partial quantitative deficiency of vWD is diagnosed as type 1 vWD. The level of vWF in the plasma, though low, can still carry out the formation of the primary hemostatic plug, and also protect Factor VIII. In most type 1 vWD cases, Factor VIII levels are very mildly affected. It is hard to accurately diagnose type 1 vWD because, the vWF levels also depend on the ABO blood grouping. The average vWF level in healthy individuals with blood type O is about 75 IU/dL. It is reasonable to classify the condition of a patient with less than 20 IU/dL vWF level as type 1 vWD because this indicates a probable hereditary mutation. The vWF:Ag and vWF:RCo tests show similar reductions in vWF activity for type 1 vWD patients compared to the reference plasma by ISTH (U.S. Department of Health and Human Services, 2007). Type 3 vWD When the vWF activity of a plasma sample is less than 10 IU/dL, it is classified as type 3 vWD.84-86 Major mutations such as frameshifts, large deletions, splice-site mutations, and missense mutations can be causes for type 3 vWD (U.S. Department of Health and Human Services, 2007). Sometimes, clearance of vWF from the blood stream due to autoimmune disorders can decrease vWF quantity in the blood to type 3 levels of vWD. This is also one of the causes of of Acquired von Willebrand Syndrome AVWS. Type 2 vWD Type 2 vWD is a qualitative deficiency of vWF, where, although the vWF may be produced in normal quantities, fails to perform its tasks effectively. Based on the defect in the von Willebrand Factor, it is mainly classified into types 2A, 2B, 2M and 2N. In type 2A vWD, the vWF platelet binding activity is decreased due to the absence or deficiency of high molecular weight multimers of vWF. There is a sharp fall in the vWF:RCo activity, but not much decrease in vWF:Ag and FVIII:C activity. This is because the vWF is still able to bind to Factor VIII. (Ruggeri ZM, 1980) The high molecular weight multimers are either degraded by proteolytic enzymes in the blood or have not been produced due to mutations in the exons of the vWF gene that code for the A2 and/or the D3 domain. (Schneppenheim R, 2001), (Sutherland JJ, 2004) . Type 2B VWD is characterized by an abnormal increase in the vWF-platelet binding affinity, which leads to depletion of large, functional VWF multimers, and also a fall in platelet numbers (Zimmerman TS, 1986) The platelets circulating in the blood stream are blocked with the mutant vWF, due to which, there is a great difficulty in the formation of the primary hemostatic plug. Thus, thrombocytopenia ensues, along with increased Ristocetin Induced Platelet Aggregation (RIPA) even at low concentrations of Ristocetin. Mutations in the A1 domain are responsible for type 2B vWD (Huizinga EG, 2002). In type 2M vWD the vWF platelet binding activity is reduced. But unlike the type 2A vWD, there is no decrease in the quantities of high molecular weight multimers. This phenomenon is only due to a decreased affinity to the Gp-1b receptors on the platelets (Ginsburg D, 1993), (Schneppenheim R, 2001), (Meyer D, 2001), (Rabinowitz I, 1992) (Mazurier C, 2001). The vWF:Ag, vWF:RCo and FVIII:C activities in types 2A and 2M vWD are similar. They can only be diagnosed based on high resolution gel electrophoresis images. (Meyer D, 2001). Another phenotype of type 2M vWD is the failure of vWF to bind to collagen in the extracellular matrix of the vascular sub-endothelium. vWD type 2N is due to the absence of vWF-Factor VIII binding. This is due to mutations in the D and D3 domains of the vWF protein (Ginsburg D, 1993), (Mazurier C, 2001). The laboratory tests for this type of vWD indicate normal levels for vWF:Ag and vWF:RCo tests, but the FVIII:C activity is only about 10% of normal levels. Acquired von Willebrand Syndrome Acquired von Willebrand Syndrome (AVWS) is type of vWD which is not genetically linked. There are three mechanisms by which it is manifested: Autoimmune reactions against vWF, Increased proteolysis of vWF by a protease ADAMTS13 (A Disintegrin And Metalloproteinase with a ThromboSpondin type 1 motif, member 13), or abnormal increase in the binding affinity of vWF to platelets or other cell surface receptors (U.S. Department of Health and Human Services, 2007). Diagnosis of vWD The diagnosis of von Willebrand Disease and its sub-type is made based on an initial review of previous health conditions and familial history of bleeding disorders, which is done in the clinic, and then obtaining plasma samples of the patient for laboratory tests.

Confucius :: essays research papers

Confucius and Lao Tzu Confucius and Lao Tzu were two highly known scholars in Ancient China. These scholars with their intellectual writings changed the views of the Chinese people. Confucius believed in the moral values and filial piety, he also wanted civic obedience. Lao Tzu was a mystical writer, his comparison between a "perfect world" and the "real world" made people think to act as loving and caring peoples. (Expand on what they thought about) Confucius was brought to the world sometime in 551 BCE in the state of Lu. Confucius was born to the name K’ung Ch’iu, and his father died when he was only 3 years old, leaving his family to a life of poverty. Even though poor, Confucius was given a fine education. Then at the age of 19, he married and had a son and two daughters, but after two years of marriage he was stricken with poverty once again. With poverty striking again he was forced into menial labors for the chief of the district in which he lived. When his mother died in 527 BCE he mourned for a long period of time. After this stage of his life he began a new way of life as a teacher, traveling from place to place with a small group of disciples preaching. His teachings of Chinese ideals and customs soon spread all throughout Lu. In his speeches he also taught the people gathered his view of filial piety and his views of moral values. Then at the age of fifty he was appointed as the minister of crime of Lu. This administration was very successful, and Confucius made Lu very powerful and free from crime. Confucius never wrote his teachings out on paper himself, however they were passed down through his disciples and later wrote out in text form in a document called "Lun Yu."(Encarta ’98, "Confucius) Lao Tzu was born sometime around 570 in the province of Henan and there he was a court librarian. Lao Tzu was not his real name; this name was given to him as an honorific title meaning "Old Master." Lao Tzu spoke to groups of people, about life the way he thought it should be, which was a natural way of life with goodness, serenity, and respect. He did not lay down any code of law of behavior; he believed that conduct came from instincts. He also believed that human life as well as everything else was influenced by outside forces, and simplicity was the key to truth and freedom.

Recycling: Very Important for the Earth Essay -- Recycling, 2015

â€Å"I think the environment should be put in the category of our national security. Defense of our resources is just as important as defense abroad. Otherwise what is there to defend?† --Robert Redford, Yosemite National Park dedication, 1985 Recycling has been around for a very long time; thousands of years to be exact. Some recycling methods then were recycling animal skins and scrap metal. Animal skins were re-used by the Indians for clothes, shoes and shelter and metal was melted down to make swords and other weapons. However, now, century’s later metal is still melted down to make things such as airplanes, cars, appliances, war weapons and much, much, more. And animal skin is still used today, to make shoes, boots and certain clothing items; such leather coats. Recycling became noticed as a trend by the public in the 1970’s. The industries have known about recycling for years. The public grabbed the concept that turning old items into new ones was just as much their duty as well as industries when the environment began to go unhealthy and when recycling centers opened. Now, curbside recycling programs and recycling centers are common. In 2009, approximately 9,000 curbside recycling programs and 3, 000 composting communities existed in the United States (EPA 2010). You can now recycle at home and in airports, schools, and the workplace. What is recycling? , What does waste consist of? , and what are the benefits of recycling? Recycling basics and steps What is recycling? Recycling can be defined as making a new product from used materials or â€Å"to adapt to a new use† and â€Å"to make ready for reuse† seem to fit best (Merriam-Webster, 2011). Don’t confused reusing with recycling. Reusing is far different from recyc... ... incineration and landfills, prevents pollution caused by the manufacturing of products from virgin materials; saves energy; decreases emissions of greenhouse gases that contribute to global climate change; conserves natural resources such as timber, water, and minerals; and helps sustain the environment for future generations (EPA 2011a and Palliser 2011). In conclusion revisiting recycling has been a great experience. Recycling is very important for the earth and clean air. We need to continue to do our part in protect the environment and making sure that landfills decrease instead of increasing and that are properly maintained. Recycling is very important for earth. Many companies are on broad with recycling doing their part to help decrease waste. Works Cited Palliser, Janna. (2011). Revisiting recycling. Science Scope. November 2011, pp. 14-17.

Week 7

* Use a spreadsheet to develop a point-scoring matrix and determine which system Mark should select. Software| Â  | Â  | Weighted Score| weighted score| weighted score| Fulfillment of business needs| 100| Â  | 600| 800| 900| Acceptance in marketplace| 30| Â  | 180| 180| 180| Quality of documentation| 50| Â  | 350| 450| 400| Quality of warranty| 50| Â  | 200| 400| 350| Ease of use| 80| Â  | 560| 480| 400| Control features| 50| Â  | 450| 350| 450| Flexibility| 20| Â  | 80| 100| 180| Security features| 30| Â  | 120| 120| 240| Modularity| 30| Â  | 240| 150| 120|Integration with other software| 30| Â  | 240| 270| 180| Quality of support utilities| 50| Â  | 450| 400| 250| Vendor| Â  | Â  | Â  | Â  | Â  | Reputation and reliability| 10| Â  | 30| 90| 60| Experience with similar systems| 20| Â  | 100| 100| 120| Installation assistance| 70| Â  | 630| 280| 430| Training assistance| 35| Â  | 140| 280| 210| Timeliness of maintenance| 35| Â  | 175| 140| 140| Hardware| Â  | Â  | Â  | Â  | Â  | Internal memory size (RAM)| 70| Â  | 350| 420| 560| Hard-drive capacity| 40| Â  | 360| 360| 200| Graphics capabilities| 50| Â  | 350| 350| 400| Processing speed| 30| Â  | 240| 240| 150|Overall performance| 40| Â  | 360| 400| 400| Expandability| 50| Â  | 350| 100| 500| Support for network technology| 30| Â  | 90| 120| 210| Â  | Â  | Â  | Â  | Â  | Â  | | Â  | Â  | 6645| 6580| 7030| * b. Susan Shelton did not agree with Mark’s weightings and suggested the following When the changes are made, which vendor should Mark recommend? Mark should recommend VENDOR 3 * c. Mark’s manager suggested the following changes to Susan’s weightings: Reputation and reliability| 90| Installation assistance| 40| Experience with similar systems| 40| Training assistance| 65| Internal memory size| 10| Will the manager’s changes affect the decision about which system to buy? Yes the sum total of all the changes will directly affect the outcome of which system they will purchase. * d. what can you conclude about point scoring from the changes made by Susan and Mark’s manager? Develop your own weighting scale to evaluate the software packages. What other selection criteria would you use? Be prepared to discuss your results with the class. I take the weighted sum of all the packages and compare them based on the scoring system and average them out to see who's strong and weak.Based on my approval I would pick the one that is nearest middle of the road compared to the other 2. This way all attributes are about equal rather than struggling with one issue and excelling at another. This would be my way of defining an accurate and realistic scoring system. * e. What are the weaknesses of the point-scoring method? Point scoring method doesn't mean it's the right scoring method. Its only good for what you are prioritizing in your goals and what you are looking for. Based on your needs and wants the scoring system may not be what you are looking for if you are going for the efficient way of grading rubrics.